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In timpul utilizarii acestui medicament este necesara monitorizare medicala atenta, in special in caz de insuficienta renala, boala cronica hepatica, alcoolism si insuficienta respiratorie.În timpul tratamentului cu Imovane există riscul de apariţie a somnolenţei. În scopul diminuării acestui risc, se recomandă un somn nocturn neîntrerupt.